Solid Dosage Form Equipment Automated Production Workflow

Solid dosage form equipment automated production workflow

1. Preparation of powders and granules

Powder dosage forms are the most basic dosage forms and are usually used as raw materials for other solid dosage forms such as tablets and capsules. The preparation of powders begins with the pulverization and homogenization of the raw material to ensure uniform particle size.

Granular dosage forms are formed by agglomerating powder particles to form larger particles, usually through wet or dry granulation.

Wet granulation: Using equipment such as high shear granulators, fluidized bed granulators, or planetary mixers, active pharmaceutical ingredients (APIs) and excipients are mixed with a liquid binder to form homogeneous granules by wetting, shearing, and squeezing. Subsequently, the wet granules need to be removed from moisture by oven, fluid bed drying or spray drying.

Dry granulation: there is no need to add liquid binder, but rely on the material's own adhesive properties to achieve the formation of granules.

2. Solid dosage form equipment tablet preparation

Tablets are made by compressing pharmaceutical raw materials and excipients into solid dosage forms. Tablet presses are the core equipment in tablet production, capable of compressing powdered or granular materials into tablets of precise size, shape and weight.

Rotary tablet presses and single punch tablet presses are common tablet presses that enable high speed production and ensure consistency of tablets.

Coating Equipment: Used to provide uniform coating on tablets and granules to improve the dissolution rate, taste and stability of the drug.

3. Solid Dosage Form Equipment Capsule Preparation

Capsule is a solid dosage form made by filling drug ingredients or particles into the capsule shell, which is categorized into hard and soft capsules.

Capsule filling machine is the key equipment in capsule production, which can ensure precise dosage and proper capsule sealing to meet the requirements of different sizes and filling processes.

4. Importance of solid dosage processing equipment

Solid dosage form processing equipment plays a vital role in pharmaceutical manufacturing to ensure quality, uniformity and productivity of drug dosage forms.Companies like hanyoo offer a wide range of solid dosage form processing equipment to help pharmaceutical companies produce high quality, uniform and efficient solid dosage forms.

5. Solid dosage form equipment selection and optimization

When selecting solid dosage form processing equipment, pharmaceutical companies need to consider the following factors:

Production scale: according to the production needs to choose the right size of equipment, such as laboratory scale, pilot scale or large-scale production equipment.

Process requirements: different drug dosage forms require different processing techniques, the choice of equipment should meet the specific process requirements.

Quality control: the equipment should have good quality control function to ensure the uniformity and stability of the drug dosage form.

Degree of automation: automated equipment can improve production efficiency, reduce human error and ensure the consistency and repeatability of production.

6. Solid dosage form equipment future development trend

With the continuous development of the pharmaceutical industry, solid dosage processing equipment is also progressing. Future trends include:

Continuous Manufacturing: Continuous manufacturing technology can increase productivity, reduce production cycles, and improve product quality consistency.

Intelligent and digital: intelligent monitoring and optimization of equipment through the introduction of Internet of Things (IoT) and big data technologies to improve the transparency and controllability of the production process.

Green Manufacturing: Reduce energy consumption and waste emissions to promote sustainable development in the pharmaceutical industry.